Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | FPR1 | P21462 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7152058 | 0.99 | NAMPT (0.49) | SMN1; SMN2NPC1TP53RAB9ANAMPT | |
| SCHEMBL1378697 | 0.86 | NAMPT (0.48) | SMN1; SMN2NPC1TP53RAB9ANAMPT | |
| SCHEMBL17507085 | 0.83 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1TP53RAB9ANAMPT | |
| SCHEMBL7150779 | 0.82 | HTT (0.63) | SMN1; SMN2NPC1TP53RAB9AMAPT | |
| SCHEMBL7149483 | 0.82 | ALDH1A1 (0.43) | SMN1; SMN2NPC1TP53RAB9ANAMPT | |
| SCHEMBL5443184 | 0.81 | MAPT (0.57) | SMN1; SMN2TP53MAPTALDH1A1KDM4E | |
| SCHEMBL1380603 | 0.80 | F10 (0.59) | NAMPTALDH1A1F10 | |
| SCHEMBL17507082 | 0.80 | GAA (0.50) | SMN1; SMN2NPC1TP53RAB9ANAMPT | |
| SCHEMBL17541774 | 0.80 | GAA (0.50) | SMN1; SMN2NPC1TP53RAB9ANAMPT | |
| SCHEMBL7088328 | 0.79 | MAPT (0.68) | SMN1; SMN2NPC1RAB9ANAMPTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351938-A1 | PHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2003-10-15 | — | — | EP | claimed |
| WO-2002057236-A1 | PHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2002-07-25 | — | — | WO | claimed |