Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 7/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | GPR4 | P46093 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 5/20 | 0.35 |
| ▸ | HRH1 | P35367 | 5/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3923435 | 0.75 | GPR4 (0.41) | EPHX2GPR4PDE3BPDE3AACKR3 | |
| SCHEMBL30597772 | 0.71 | KDM4E (0.49) | FLT3 | |
| SCHEMBL13291530 | 0.66 | PSMB1 (0.48) | GPR4FLT3 | |
| SCHEMBL3921357 | 0.66 | GPR4 (0.43) | EPHX2RXFP1GPR4PDE3BPDE3A | |
| SCHEMBL20423457 | 0.66 | DRD3 (0.55) | EPHX2GPR4HRH2HRH1DRD2 | |
| SCHEMBL30812113 | 0.65 | EPHX2 (0.60) | EPHX2RXFP1GPR4DRD2DRD3 | |
| SCHEMBL13291514 | 0.65 | BRD4 (0.49) | EPHX2GPR4 | |
| SCHEMBL216291 | 0.64 | EPHX2 (0.52) | EPHX2GPR4DRD2DRD3ACKR3 | |
| SCHEMBL31245991 | 0.64 | EPHX2 (0.59) | EPHX2RXFP1GPR4DRD2DRD3 | |
| SCHEMBL19479118 | 0.64 | DRD3 (0.70) | HRH2HRH1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732938-B1 | ORGANOPHOSPHOROUS INDAZOLE DERIVATIVES AND USE THEREOF AS PROTEIN KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2009-05-06 | — | — | EP | disclosed |