Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4485751 | 1.00 | KMT2A (0.60) | KMT2AALDH1A1HIF1ASMN1; SMN2TSHR | |
| SCHEMBL114077 | 0.86 | KMT2A (0.65) | KMT2AALDH1A1HIF1ASMN1; SMN2TSHR | |
| SCHEMBL29288675 | 0.84 | KMT2A (0.63) | KMT2AALDH1A1HIF1ASMN1; SMN2TSHR | |
| SCHEMBL25090606 | 0.84 | ALDH1A1 (0.53) | KMT2AALDH1A1HIF1ASMN1; SMN2TSHR | |
| SCHEMBL1654660 | 0.84 | ALDH1A1 (0.59) | KMT2AALDH1A1HIF1ASMN1; SMN2LMNA | |
| SCHEMBL195145 | 0.84 | ALDH1A1 (0.59) | KMT2AALDH1A1HIF1ASMN1; SMN2LMNA | |
| SCHEMBL6398309 | 0.83 | KMT2A (0.71) | KMT2AALDH1A1SMN1; SMN2TSHRLMNA | |
| Silver SCHEMBL887047 | 0.82 | ALDH1A1 (0.55) | KMT2AALDH1A1HIF1ASMN1; SMN2LMNA | |
| SCHEMBL2832 | 0.82 | ALDH1A1 (0.55) | KMT2AALDH1A1HIF1ASMN1; SMN2LMNA | |
| SCHEMBL284069 | 0.82 | ALDH1A1 (0.55) | KMT2AALDH1A1HIF1ASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009058919-A1 | CCR5 ANTAGONISTS AS THERAPEUTIC AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-05-07 | — | — | WO | disclosed |