Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 1/20 | 0.54 |
| ▸ | CCNC | P24863 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 16/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11852402 | 0.72 | PDE5A (0.64) | CLK1PDE5AEGFRABL1PDGFRB | |
| SCHEMBL1675243 | 0.70 | CLK1 (1.00) | CLK1EGFR | |
| SCHEMBL8351408 | 0.68 | MAPK1 (0.67) | CLK1HTTEGFRSRC | |
| SCHEMBL13844526 | 0.68 | EGFR (0.62) | CCNCHTTCDK8EGFRSRC | |
| SCHEMBL13844488 | 0.67 | KIT (0.36) | EGFRABL1PDGFRBFGFR1SRC | |
| SCHEMBL4359487 | 0.66 | HTT (1.00) | CLK1CCNCHTTCDK8 | |
| SCHEMBL6797080 | 0.66 | EGFR (0.81) | EGFRABL1PDGFRBFGFR1SRC | |
| SCHEMBL20865333 | 0.66 | EGFR (0.70) | EGFRABL1PDGFRBFGFR1SRC | |
| SCHEMBL23339883 | 0.65 | RXFP1 (0.60) | CCNCHTTCDK8PDE5A | |
| SCHEMBL19908373 | 0.65 | EGFR (0.71) | EGFRABL1PDGFRBFGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009057139-A2 | NOVEL 4-(TETRAZOL-5-YL)-QUINAZOLINE DERIVATIVES AS ANTI CANCER AGENTS | NATCO PHARMA LIMITED (IN) | 2009-05-07 | — | — | WO | disclosed |