SCHEMBL1384474

SCHEMBL1384474

NC(=O)c1[nH]nc2ncccc12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3A P49840 1/20 0.48
GSK3B P49841 1/20 0.48
APP P05067 4/20 0.46
PIK3CA P42336 2/20 0.42
MTOR P42345 2/20 0.42
CCNA2 P20248 1/20 0.42
CDK2 P24941 1/20 0.42
CCNA1 P78396 1/20 0.42
KDM4E B2RXH2 1/20 0.41
IKBKB O14920 1/20 0.41
CHUK O15111 1/20 0.41
LIMK1 P53667 1/20 0.41
ACHE P22303 6/20 0.40
CAMKK2 Q96RR4 1/20 0.39
BCHE P06276 3/20 0.39
CYP2C9 P11712 1/20 0.38
GRM5 P41594 1/20 0.38
CLK2 P49760 1/20 0.38
CLK3 P49761 1/20 0.38
DYRK1A Q13627 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1048846 0.84 GSK3B (0.49) GSK3AGSK3BAPPPIK3CAMTOR
SCHEMBL3638216 0.83 PIK3CA (0.42) GSK3AGSK3BAPPPIK3CAMTOR
SCHEMBL1554782 0.82 GSK3A (0.51) GSK3AGSK3BAPPKDM4EACHE
SCHEMBL2172066 0.73 CCNA2 (0.54) MTORCCNA2CDK2CCNA1KDM4E
SCHEMBL6649449 0.73 CYP1A2 (0.47) PIK3CAMTORCCNA2CDK2CCNA1
SCHEMBL23830302 0.72 PARP1 (0.45) CCNA2CDK2CCNA1KDM4EIKBKB
SCHEMBL1689336 0.72 CCNA2 (0.42) CCNA2CDK2CCNA1LIMK1CLK2
SCHEMBL1164088 0.72 GSK3B (0.50) GSK3AGSK3BAPPPIK3CAMTOR
Hydrochloric Acid SCHEMBL20529735 0.71 CCNA2 (0.41) GSK3AGSK3BAPPCCNA2CDK2
SCHEMBL1637594 0.71 PIK3CA (0.50) GSK3AGSK3BAPPPIK3CAMTOR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4460301-A1 SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES Universität zu Köln (DE) 2024-11-13 EP claimed
WO-2023131576-A1 SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES UNIVERSITÄT ZU KÖLN (DE) 2023-07-13 WO claimed
EP-2699576-A1 PYRAZOLOSPIROKETONE DERIVATIVES FOR USE AS ACETYL - COA CARBOXYLASE INHIBITORS Pfizer Inc (US) 2014-02-26 EP claimed
WO-2012143813-A1 PYRAZOLOSPIROKETONE DERIVATIVES FOR USE AS ACETYL - COA CARBOXYLASE INHIBITORS PFIZER INC. (US) 2012-10-26 WO claimed
JP-4814783-B2 2011-11-16 JP claimed
EP-2265335-A1 INDAZOLE DERIVATIVES Pfizer Inc. (US) 2010-12-29 EP claimed
WO-2009106982-A1 INDAZOLE DERIVATIVES PFIZER INC. (US) 2009-09-03 WO claimed
WO-2009106980-A2 INDAZOLE DERIVATIVES PFIZER INC. (US) 2009-09-03 WO claimed
EP-4525853-A1 METHODS AND COMPOSITIONS FOR TREATING FATTY LIVER AND VIRAL INFECTIONS The Board of Trustees of the Leland Stanford Junior University (US) 2025-03-26 EP disclosed
EP-4460301-A1 SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES Universität zu Köln (DE) 2024-11-13 EP disclosed
WO-2023225324-A1 METHODS AND COMPOSITIONS FOR TREATING FATTY LIVER AND VIRAL INFECTIONS THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2023-11-23 WO disclosed
WO-2023131576-A1 SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES UNIVERSITÄT ZU KÖLN (DE) 2023-07-13 WO disclosed
WO-2023025109-A1 TOLL-LIKE RECEPTOR INHIBITOR AND PREPARATION AND APPLICATION THEREOF 上海维申医药有限公司 2023-03-02 WO disclosed
EP-3036230-A1 ALKYNYL ALCOHOLS AND METHODS OF USE F. Hoffmann-La Roche AG (CH) 2016-06-29 EP disclosed
EP-2265335-A1 INDAZOLE DERIVATIVES Pfizer Inc. (US) 2010-12-29 EP disclosed
WO-2009106982-A1 INDAZOLE DERIVATIVES PFIZER INC. (US) 2009-09-03 WO disclosed
WO-2009106980-A2 INDAZOLE DERIVATIVES PFIZER INC. (US) 2009-09-03 WO disclosed
EP-2089018-A2 METHODS OF TREATING COGNITIVE IMPAIRMENT AND DEMENTIA Lexicon Pharmaceuticals, Inc. (US) 2009-08-19 EP disclosed
WO-2008067121-A2 METHODS OF TREATING COGNITIVE IMPAIRMENT AND DEMENTIA LEXICON PHARMACEUTICALS, INC. (US) 2008-06-05 WO disclosed
WO-2006124897-A2 METHODS AND COMPOSITIONS FOR IMPROVING COGNITION LEXICON GENETICS INCORPORATED (US) 2006-11-23 WO disclosed