Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 5/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 7/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | CLK3 | P49761 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 4/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1384474 | 0.82 | GSK3A (0.48) | GSK3AGSK3BAPPKDM4EACHE | |
| SCHEMBL1048846 | 0.80 | GSK3B (0.49) | GSK3AGSK3BAPPKDM4EACHE | |
| SCHEMBL3638216 | 0.76 | PIK3CA (0.42) | GSK3AGSK3BAPPACHEBCHE | |
| SCHEMBL1554784 | 0.73 | KDM4E (0.60) | GSK3AGSK3BP2RX7RAB9AKDM4E | |
| SCHEMBL1164088 | 0.69 | GSK3B (0.50) | GSK3AGSK3BAPPKDM4EACHE | |
| SCHEMBL17363782 | 0.68 | PIK3CA (0.44) | GSK3AGSK3BAPPACHENTRK1 | |
| SCHEMBL1637594 | 0.68 | PIK3CA (0.50) | GSK3AGSK3BAPPKDM4EACHE | |
| SCHEMBL1558073 | 0.67 | MAP2K1 (0.63) | P2RX7CLK2DYRK1A | |
| SCHEMBL1343939 | 0.66 | PIK3CA (0.49) | GSK3AGSK3BAPPKDM4EACHE | |
| SCHEMBL5532626 | 0.65 | GSK3A (0.39) | GSK3AGSK3BAPPP2RX7RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488519-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS ANTICANCER AGENT | Pierre Fabre Médicament (FR) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011045344-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS ANTICANCER AGENT | PIERRE FABRE MEDICAMENT (FR) | 2011-04-21 | — | — | WO | disclosed |