Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | FRK | P42685 | 1/20 | 0.35 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18208663 | 0.84 | KDM4E (0.40) | PARP1KDM4EL3MBTL1MAPTCDK9 | |
| SCHEMBL2172066 | 0.73 | CCNA2 (0.54) | PARP1CCNA2CDK2CCNA1KDM4E | |
| SCHEMBL6649449 | 0.73 | CYP1A2 (0.47) | CCNA2CDK2CCNA1KDM4EPDPK1 | |
| SCHEMBL5084936 | 0.72 | CCNA2 (0.39) | CCNA2CDK2CCNA1RPS6KB1PDPK1 | |
| SCHEMBL1384474 | 0.72 | GSK3A (0.48) | PARP1CCNA2CDK2CCNA1KDM4E | |
| SCHEMBL2330553 | 0.72 | MAPT (0.48) | CCNA2CDK2KDM4EMKNK2MKNK1 | |
| Hydrochloric Acid SCHEMBL20529735 | 0.71 | CCNA2 (0.41) | PARP1CCNA2CDK2CCNA1KDM4E | |
| SCHEMBL31222504 | 0.70 | PARP1 (0.43) | PARP1CDK2KDM4ELIMK1MKNK2 | |
| SCHEMBL29455053 | 0.69 | PARP1 (0.45) | PARP1KDM4ELIMK1RPS6KB1ITK | |
| SCHEMBL3219167 | 0.69 | PARP1 (0.45) | PARP1KDM4ELIMK1RPS6KB1ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220213092-A1 | BICYCLIC PYRAZOLE BRUTON'S TYROSINE KINASE INHIBITORS | ABBVIE INC (US) | 2022-07-07 | — | — | US | disclosed |
| WO-2022132997-A1 | BICYCLIC PYRAZOLE BRUTON'S TYROSINE KINASE INHIBITORS | ABBVIE INC. (US) | 2022-06-23 | — | — | WO | disclosed |
| US-20210292333-A1 | CONDENSED AZAHETEROARYL COMPOUNDS HAVING ANTIBACTERIAL ACTIVITY AGAINST TUBERCULOSIS BACTERIA | CADILA HEALTHCARE LIMITED (IN) | 2021-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213092-A1 | BICYCLIC PYRAZOLE BRUTON'S TYROSINE KINASE INHIBITORS | BTK, LYN, ABL1 | PARP1 833/4885CCNA2 526/4885CDK2 40/4885 |
| US-20210292333-A1 | CONDENSED AZAHETEROARYL COMPOUNDS HAVING ANTIBACTERIAL ACTIVITY AGAINST TUBERCULOSIS BACTERIA | DPEP1, SAT1, PEPD | PARP1 1894/4885CCNA2 2043/4885CDK2 850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.