Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 13/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1265157 | 0.81 | JAK2 (0.58) | USP1ADORA3TRAP1JAK2JAK3 | |
| SCHEMBL30110671 | 0.81 | ADORA3 (0.62) | USP1ADORA3 | |
| SCHEMBL3850488 | 0.77 | USP1 (0.44) | USP1ADORA3 | |
| SCHEMBL3850496 | 0.77 | USP1 (0.42) | USP1ADORA3 | |
| SCHEMBL3850492 | 0.77 | USP1 (0.42) | USP1ADORA3 | |
| SCHEMBL3845689 | 0.74 | USP1 (0.43) | USP1ADORA3 | |
| SCHEMBL13608406 | 0.71 | ADORA3 (0.47) | USP1ADORA3 | |
| SCHEMBL23392983 | 0.70 | MTOR (0.55) | USP1ADORA3TRAP1 | |
| SCHEMBL30110559 | 0.70 | MTOR (0.55) | USP1ADORA3TRAP1 | |
| SCHEMBL7210910 | 0.70 | ADORA3 (0.84) | USP1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009062059-A2 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-05-14 | — | — | WO | disclosed |