Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13978066 | 0.87 | PRKCQ (0.50) | PTGER4IRAK1PRKCQCYP3A4CYP2C9 | |
| SCHEMBL13608140 | 0.81 | PIK3CA (0.40) | ACP1IRAK4IRAK1PIK3CACHRM3 | |
| SCHEMBL13845177 | 0.80 | PRKCQ (0.51) | IRAK4IRAK1TYRO3PRKCQCYP3A4 | |
| SCHEMBL13978067 | 0.77 | PRKCQ (0.45) | IRAK1TYRO3PRKCQCYP3A4CYP2C9 | |
| SCHEMBL13978061 | 0.77 | PRKCQ (0.58) | IRAK1PRKCQCYP3A4CYP2C9 | |
| SCHEMBL13845174 | 0.75 | PRKCQ (0.48) | IRAK1TYRO3PRKCQCYP3A4CYP2C9 | |
| SCHEMBL13608118 | 0.73 | FYN (0.38) | ACP1IRAK4IRAK1TYRO3 | |
| SCHEMBL13978063 | 0.73 | PRKCQ (0.56) | IRAK1PRKCQCYP3A4CYP2C9 | |
| SCHEMBL13978062 | 0.73 | PRKCQ (0.46) | IRAK1TYRO3PRKCQCYP3A4CYP2C9 | |
| SCHEMBL13978291 | 0.73 | ACACB (0.40) | PRKCQCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009062059-A2 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-05-14 | — | — | WO | disclosed |