Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 12/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | CDK1 | P06493 | 3/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.40 |
| ▸ | STK3 | Q13188 | 2/20 | 0.40 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13845177 | 0.87 | PRKCQ (0.51) | PRKCQCYP3A4CYP2C9KDM1ACDK2 | |
| SCHEMBL13845160 | 0.77 | KDM1A (0.41) | PRKCQCYP3A4CYP2C9KDM1AIRAK1 | |
| SCHEMBL13845164 | 0.75 | ACP1 (0.41) | PRKCQCYP3A4CYP2C9IRAK1TYRO3 | |
| SCHEMBL13845192 | 0.74 | PRKCQ (0.44) | PRKCQKDM1AIRAK1AURKBCHEK1 | |
| SCHEMBL12641070 | 0.73 | PRKCQ (0.53) | PRKCQCYP3A4CYP2C9KDM1ACHEK1 | |
| SCHEMBL13720137 | 0.72 | PRKCQ (0.71) | PRKCQCYP3A4CYP2C9CDK2CDK1 | |
| SCHEMBL13845154 | 0.70 | PRKCQ (0.46) | PRKCQAXLFLT3TYRO3MERTK | |
| Tert-Butyl Formate SCHEMBL29290154 | 0.70 | CHEK1 (0.42) | PRKCQKDM1AIRAK1FLT3CHEK1 | |
| SCHEMBL12580327 | 0.69 | PRKCQ (0.57) | PRKCQCYP3A4CYP2C9KDM1APRKCD | |
| SCHEMBL13805675 | 0.68 | PRKCQ (0.70) | PRKCQCYP3A4CYP2C9CDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009062059-A2 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-05-14 | — | — | WO | disclosed |