Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.35 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | ACP1 | P24666 | 5/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.33 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13845141 | 0.94 | GBA1 (0.34) | — | |
| SCHEMBL13845192 | 0.82 | PRKCQ (0.44) | BRD4 | |
| SCHEMBL13845154 | 0.72 | PRKCQ (0.46) | MERTK | |
| SCHEMBL13845160 | 0.71 | KDM1A (0.41) | MERTKBRD4 | |
| SCHEMBL13845256 | 0.69 | HRH4 (0.38) | HRH3HRH4KMT2ACYP2D6CXCR4 | |
| SCHEMBL27987459 | 0.64 | HRH3 (0.46) | HRH3HRH4 | |
| SCHEMBL28060777 | 0.63 | HRH3 (0.49) | HRH3HRH4KMT2ACYP2D6CXCR4 | |
| SCHEMBL3443417 | 0.63 | KMT2A (0.57) | HRH3HRH4KMT2A | |
| SCHEMBL3443170 | 0.63 | KMT2A (0.57) | HRH3HRH4KMT2A | |
| SCHEMBL3443727 | 0.63 | KMT2A (0.57) | HRH3HRH4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009062059-A2 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-05-14 | — | — | WO | disclosed |