Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 8/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 2/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.34 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16487153 | 0.81 | LMNA (0.49) | LMNATSHRHSP90AA1ERBB2HSP90AB1 | |
| SCHEMBL3116678 | 0.78 | LMNA (0.68) | LMNATSHRHSP90AA1ERBB2HSP90AB1 | |
| SCHEMBL5132695 | 0.78 | LMNA (0.48) | LMNATSHRPI4KAPI4K2BPI4K2A | |
| SCHEMBL3115737 | 0.76 | PIK3CD (0.44) | PIK3CGLMNATSHRHSP90AA1ERBB2 | |
| SCHEMBL17781994 | 0.76 | PTGIR (0.41) | PIK3CGLMNATSHRHSP90AA1ERBB2 | |
| SCHEMBL13079975 | 0.76 | GAA (0.41) | TSHRHSP90AA1ERBB2HSP90AB1MAP4K4 | |
| SCHEMBL13845726 | 0.76 | HSP90AA1 (0.38) | PIK3CGLMNATSHRHSP90AA1ERBB2 | |
| SCHEMBL16487211 | 0.75 | HSP90B1 (0.44) | LMNATSHRHSP90AA1ERBB2HSP90AB1 | |
| SCHEMBL16487138 | 0.75 | LMNA (0.46) | LMNATSHRHSP90AA1ERBB2HSP90AB1 | |
| SCHEMBL16486508 | 0.75 | LMNA (0.49) | LMNATSHRHSP90AA1ERBB2HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009065035-A1 | THERAPEUTIC COMPOUNDS AND THEIR USE IN TREATING DISEASES AND DISORDERS | MYRIAD GENETICS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |