Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.55 |
| ▸ | MET | P08581 | 4/20 | 0.46 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.44 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.44 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL488288 | 0.92 | KCNH2 (0.56) | KCNH2METBMPR1BBMPR1AACVRL1 | |
| SCHEMBL30454652 | 0.92 | KCNH2 (0.56) | KCNH2METBMPR1BBMPR1AACVRL1 | |
| SCHEMBL488565 | 0.82 | KCNH2 (0.55) | KCNH2METBMPR1BBMPR1AACVRL1 | |
| SCHEMBL30453581 | 0.82 | KCNH2 (0.55) | KCNH2METBMPR1BBMPR1AACVRL1 | |
| SCHEMBL30453650 | 0.81 | MET (0.65) | KCNH2METBMPR1BBMPR1AACVRL1 | |
| SCHEMBL488012 | 0.81 | MET (0.65) | KCNH2METBMPR1BBMPR1AACVRL1 | |
| SCHEMBL488031 | 0.79 | MET (0.57) | METAXLMERTK | |
| SCHEMBL30454737 | 0.79 | MET (0.57) | METAXLMERTK | |
| SCHEMBL488207 | 0.78 | MET (0.56) | KCNH2MET | |
| SCHEMBL30453281 | 0.78 | MET (0.56) | KCNH2MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4695588-B2 | — | — | 2011-06-08 | — | — | JP | claimed |
| JP-2006519232-A | — | — | 2006-08-24 | — | — | JP | claimed |
| EP-1603570-A2 | AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2005-12-14 | — | — | EP | claimed |
| WO-2004076412-A2 | AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | SUGEN, INC. (US) | 2004-09-10 | — | — | WO | claimed |