Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 2/20 | 0.61 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.55 |
| ▸ | NAMPT | P43490 | 3/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | TOP2A | P11388 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13575608 | 1.00 | HTR4 (0.61) | HTR4SMYD3NAMPTROCK2TDP1 | |
| SCHEMBL13846092 | 1.00 | HTR4 (0.61) | HTR4SMYD3NAMPTROCK2TDP1 | |
| SCHEMBL13846145 | 0.93 | HTR4 (0.59) | HTR4SMYD3ROCK2TDP1PKN2 | |
| SCHEMBL13846148 | 0.93 | HTR4 (0.59) | HTR4SMYD3ROCK2TDP1PKN2 | |
| SCHEMBL13846080 | 0.93 | HTR4 (0.67) | HTR4SMYD3ROCK2TDP1BRD4 | |
| SCHEMBL4802575 | 0.88 | HTR4 (0.72) | HTR4ROCK2TDP1MAPK14F10 | |
| SCHEMBL13175546 | 0.85 | HTR4 (0.69) | HTR4TDP1MAPK14F10 | |
| SCHEMBL13175812 | 0.85 | HTR4 (0.69) | HTR4ROCK2TDP1MAPK14F10 | |
| SCHEMBL13175544 | 0.84 | TDP1 (0.69) | HTR4TDP1MAPK14 | |
| SCHEMBL13175541 | 0.82 | HTR4 (0.66) | HTR4NAMPTROCK2TDP1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067547-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-05-28 | — | — | WO | disclosed |