Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21088943 | 0.98 | EPHX1 (0.41) | SMN1; SMN2HSD17B10EPHX1KDM4EALDH1A1 | |
| SCHEMBL18172527 | 0.82 | KDM4E (0.30) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3666819 | 0.81 | EPHX2 (0.41) | SMN1; SMN2HSD17B10EPHX1KDM4EALDH1A1 | |
| SCHEMBL11888848 | 0.81 | PDK1 (0.39) | SMN1; SMN2HSD17B10EPHX1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL1458776 | 0.79 | EPHX2 (0.40) | SMN1; SMN2HSD17B10EPHX1KDM4EALDH1A1 | |
| SCHEMBL1459251 | 0.78 | EPHX1 (0.44) | SMN1; SMN2HSD17B10EPHX1KDM4EALDH1A1 | |
| SCHEMBL21089276 | 0.77 | EPHX1 (0.47) | SMN1; SMN2HSD17B10EPHX1KDM4EPOLB | |
| SCHEMBL1203989 | 0.77 | POLB (0.46) | HSD17B10KDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL3988453 | 0.75 | POLB (0.48) | HSD17B10EPHX1KDM4EALDH1A1POLB | |
| SCHEMBL9285591 | 0.73 | KDM4E (0.39) | SMN1; SMN2HSD17B10EPHX1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067547-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-05-28 | — | — | WO | disclosed |