Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 12/20 | 0.42 |
| ▸ | SRC | P12931 | 8/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 11/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.41 |
| ▸ | PRKCA | P17252 | 4/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | PRKCH | P24723 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2356340 | 0.91 | STK17A (0.46) | STK17AABL1SRCEGFRBCR | |
| SCHEMBL13846245 | 0.81 | ABL1 (0.53) | ABL1SRCEGFRBCRPDGFRB | |
| SCHEMBL2358496 | 0.79 | JAK2 (0.51) | STK17AABL1SRCBCRPDGFRB | |
| SCHEMBL13846259 | 0.79 | SYK (0.45) | ABL1SRCEGFRBCRPDGFRB | |
| SCHEMBL3313243 | 0.79 | STK17A (0.45) | STK17AABL1PRKCDPRKCGPRKCQ | |
| SCHEMBL4409761 | 0.79 | STK17A (0.45) | STK17AABL1PRKCDPRKCGPRKCQ | |
| SCHEMBL2359321 | 0.78 | STK17A (0.48) | STK17AABL1SRCBCRPDGFRB | |
| SCHEMBL2357620 | 0.76 | ABL1 (0.52) | STK17AABL1SRCBCRPDGFRB | |
| SCHEMBL2358444 | 0.76 | ABL1 (0.48) | STK17AABL1SRCEGFRBCR | |
| SCHEMBL2356976 | 0.75 | CDK2 (0.52) | STK17AABL1SRCBCRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009064835-A1 | 4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-05-22 | — | — | WO | disclosed |