Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 13/20 | 0.46 |
| ▸ | JAK3 | P52333 | 9/20 | 0.46 |
| ▸ | JAK1 | P23458 | 7/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.44 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | OPA1 | O60313 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706502 | 0.90 | JAK2 (0.49) | CDK2KCNH2JAK2JAK3JAK1 | |
| SCHEMBL3311268 | 0.89 | JAK2 (0.50) | CDK2KCNH2JAK2JAK3JAK1 | |
| SCHEMBL13846212 | 0.88 | JAK2 (0.48) | CDK2JAK2JAK3JAK1TYK2 | |
| SCHEMBL13846262 | 0.85 | JAK2 (0.44) | CDK2JAK2JAK3JAK1TYK2 | |
| SCHEMBL13846361 | 0.84 | CDK1 (0.43) | CDK2JAK2JAK3JAK1TYK2 | |
| SCHEMBL13846274 | 0.84 | JAK2 (0.56) | CDK2JAK2JAK3JAK1TYK2 | |
| SCHEMBL13846266 | 0.83 | JAK2 (0.44) | CDK2JAK2JAK3JAK1TYK2 | |
| SCHEMBL13595268 | 0.83 | IKBKB (0.44) | CDK2JAK2JAK3JAK1TYK2 | |
| SCHEMBL13846272 | 0.82 | CDK1 (0.43) | CDK2JAK2JAK3JAK1TYK2 | |
| SCHEMBL13846365 | 0.82 | JAK2 (0.43) | CDK2JAK2JAK3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009064835-A1 | 4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-05-22 | — | — | WO | disclosed |