Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 10/20 | 0.38 |
| ▸ | FLT3 | P36888 | 7/20 | 0.38 |
| ▸ | JAK3 | P52333 | 6/20 | 0.38 |
| ▸ | TYK2 | P29597 | 6/20 | 0.38 |
| ▸ | JAK1 | P23458 | 5/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712026 | 0.92 | JAK2 (0.47) | ROCK2CSNK2A1JAK2FLT3JAK3 | |
| SCHEMBL13846268 | 0.84 | IGF1R (0.45) | ROCK2JAK2JAK3CDK2PTK2 | |
| SCHEMBL13846293 | 0.82 | IRAK4 (0.44) | JAK2TYK2CCNE1CDK2 | |
| SCHEMBL13846263 | 0.82 | IRAK4 (0.44) | JAK2TYK2CCNE1CDK2 | |
| SCHEMBL13846369 | 0.82 | LRRK2 (0.46) | JAK2CDK2 | |
| SCHEMBL13846297 | 0.81 | LRRK2 (0.43) | JAK2TYK2PAK1CCNE1CDK2 | |
| SCHEMBL13846277 | 0.81 | JAK2 (0.43) | JAK2FLT3JAK3TYK2JAK1 | |
| SCHEMBL13846280 | 0.81 | LRRK2 (0.44) | JAK2JAK3TYK2JAK1CCNE1 | |
| SCHEMBL13846362 | 0.80 | LRRK2 (0.44) | JAK2TYK2CCNE1CDK2PTK2 | |
| SCHEMBL13846298 | 0.79 | LRRK2 (0.46) | JAK2JAK3TYK2JAK1PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009064835-A1 | 4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-05-22 | — | — | WO | disclosed |