Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 4/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.39 |
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3442305 | 0.85 | MEN1 (0.42) | SLC2A1MAPK1EGFR | |
| SCHEMBL5212674 | 0.84 | GSK3B (0.43) | SLC2A1MAPK9MAPK8IGF1RMAPK10 | |
| SCHEMBL13848066 | 0.83 | TGFBR1 (0.42) | SLC2A1MAPK9MAPK8IGF1RMAPK10 | |
| SCHEMBL14593062 | 0.81 | GSK3B (0.55) | SLC2A1MAPK9MAPK8MAPK1MAPK14 | |
| SCHEMBL14515374 | 0.79 | GSK3B (0.56) | SLC2A1MAPK9MAPK8MAPK10AURKA | |
| SCHEMBL13848117 | 0.74 | GSK3B (0.59) | SLC2A1MAPK9MAPK8IGF1RMAPK10 | |
| SCHEMBL5423245 | 0.72 | PDE4B (0.41) | MAPK9MAPK10MAPK14PDE4BPDE10A | |
| SCHEMBL3441979 | 0.70 | MEN1 (0.42) | SLC2A1MAPK1EGFR | |
| SCHEMBL14593090 | 0.69 | MAPK14 (0.49) | MAPK9MAPK8IGF1RMAPK10MAPK1 | |
| SCHEMBL3441833 | 0.68 | MAPK1 (0.43) | SLC2A1MAPK9MAPK8IGF1RMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828185-B1 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2007067506-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-14 | — | — | WO | disclosed |