Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.62 |
| ▸ | ACHE | P22303 | 1/20 | 0.61 |
| ▸ | HRH1 | P35367 | 1/20 | 0.60 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.59 |
| ▸ | AKT1 | P31749 | 1/20 | 0.57 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.56 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.55 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13848167 | 0.91 | PIK3CA (0.69) | PIK3CAACHEPIK3CGPIK3CBMAP3K12 | |
| SCHEMBL13848181 | 0.91 | PIK3CA (0.73) | PIK3CAACHEPIK3CGPIK3CBMAP3K12 | |
| SCHEMBL13848250 | 0.90 | PIK3CA (0.65) | PIK3CAACHEHRH1HRH4PIK3CG | |
| SCHEMBL13848256 | 0.87 | PIK3CA (0.73) | PIK3CAPIK3CGPIK3CBMAP3K12PIK3R1 | |
| SCHEMBL13848253 | 0.83 | ADK (0.57) | PIK3CAPIK3CGPIK3CBMAP3K12PIK3R1 | |
| SCHEMBL13848236 | 0.82 | PIK3CA (0.72) | PIK3CAPIK3CGPIK3CBMAP3K12PIK3R1 | |
| SCHEMBL13848174 | 0.82 | PIK3CA (0.83) | PIK3CAPIK3CGPIK3CBMAP3K12PIK3R1 | |
| SCHEMBL10327936 | 0.82 | PIK3CA (0.65) | PIK3CAPIK3CGPIK3CBMAP3K12PIK3R1 | |
| SCHEMBL10328285 | 0.82 | PIK3CA (0.67) | PIK3CAACHEHRH1HRH4PIK3CG | |
| SCHEMBL13848242 | 0.82 | PIK3CA (0.59) | PIK3CAPIK3CGPIK3CBMAP3K12PIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | disclosed |