Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PI4KA | P42356 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300799 | 0.91 | PIK3CD (0.43) | KDM4EL3MBTL1HRH3MAPTNPC1 | |
| SCHEMBL19697169 | 0.84 | APP (0.41) | KDM4EL3MBTL1HRH3MAPTNPC1 | |
| SCHEMBL30563568 | 0.81 | SMN1; SMN2 (0.55) | KDM4EL3MBTL1MAPTNPC1RAB9A | |
| SCHEMBL28708911 | 0.81 | SMN1; SMN2 (0.55) | KDM4EL3MBTL1MAPTNPC1RAB9A | |
| SCHEMBL13185115 | 0.80 | PIK3CD (0.45) | KDM4EL3MBTL1HRH3MAPTNPC1 | |
| SCHEMBL9388103 | 0.79 | MAPT (0.44) | KDM4EL3MBTL1HRH3MAPTNPC1 | |
| SCHEMBL9908278 | 0.79 | HRH3 (0.47) | KDM4EHRH3SMN1; SMN2 | |
| SCHEMBL12141547 | 0.79 | MAPT (0.52) | KDM4EL3MBTL1HRH3MAPTNPC1 | |
| SCHEMBL11929545 | 0.78 | KDM4E (0.42) | KDM4EMAPTNPC1RAB9APIK3CD | |
| SCHEMBL21323265 | 0.77 | GABRP (0.43) | KDM4EL3MBTL1HRH3ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528163-B2 | N,N-Dibutyl-2-[3-(2,2-dimethylpropanoyl)-6-methoxy-1H-indazol-1-yl]acetamide; potassium channel blocker; eye neuroprotectant; hypotensive agent; glaucoma, intraoccular pressure in the eye | MERCK & CO. INC. (US) | 2009-05-05 | — | — | US | disclosed |