Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | EGLN1 | Q9GZT9 | 15/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28055145 | 0.83 | ALDH1A1 (0.56) | ALDH1A1EGLN1PIM1MEN1LMNA | |
| SCHEMBL2143783 | 0.80 | EGLN1 (0.60) | ALDH1A1EGLN1MEN1LMNAKMT2A | |
| SCHEMBL2143826 | 0.80 | ALDH1A1 (0.60) | ALDH1A1EGLN1 | |
| SCHEMBL4060281 | 0.78 | EGLN1 (0.65) | ALDH1A1EGLN1PIM1 | |
| SCHEMBL2143770 | 0.78 | EGLN1 (0.62) | ALDH1A1EGLN1BCHE | |
| SCHEMBL4060285 | 0.78 | EGLN1 (0.65) | ALDH1A1EGLN1PIM1 | |
| SCHEMBL2143868 | 0.77 | ALDH1A1 (0.57) | ALDH1A1EGLN1L3MBTL1BCHE | |
| SCHEMBL2143852 | 0.76 | ALDH1A1 (0.62) | ALDH1A1EGLN1LMNAKMT2AL3MBTL1 | |
| SCHEMBL27888923 | 0.75 | EGLN1 (0.63) | ALDH1A1EGLN1PIM1 | |
| SCHEMBL2017299 | 0.74 | ALDH1A1 (0.60) | ALDH1A1EGLN1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326865-B1 | AZA- AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2009-05-06 | — | — | EP | disclosed |