Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 0.54 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12311932 | 0.92 | HRH3 (0.49) | HRH3TLR9TLR8TLR7 | |
| SCHEMBL13849347 | 0.89 | HRH3 (0.54) | HRH3TLR9TLR8TLR7 | |
| SCHEMBL13849431 | 0.85 | HRH3 (0.56) | HRH3TLR9TLR8TLR7 | |
| SCHEMBL1911849 | 0.84 | TGFBR1 (0.52) | HRH3TLR9TLR8TLR7 | |
| SCHEMBL16502110 | 0.81 | HIF1A (0.48) | — | |
| SCHEMBL12311803 | 0.80 | PDE3B (0.48) | — | |
| SCHEMBL12311795 | 0.78 | OXTR (0.50) | HRH3 | |
| SCHEMBL12030651 | 0.77 | HRH3 (0.68) | HRH3 | |
| SCHEMBL13415003 | 0.77 | SYK (0.43) | HRH3 | |
| SCHEMBL12311802 | 0.77 | ACVR1B (0.51) | HRH3TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131436-A1 | Pyrimidine Derivatives | NOVARTIS AG (CH) | 2009-05-21 | — | — | US | disclosed |
| US-20090131436-A1 | Pyrimidine Derivatives | NOVARTIS AG (CH) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131436-A1 | Pyrimidine Derivatives | DPYD, TYMP, TYMS | HRH3 2767/4885TLR9 3740/4885TLR8 4542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.