Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.51 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.51 |
| ▸ | AHR | P35869 | 1/20 | 0.51 |
| ▸ | FADS1 | O60427 | 1/20 | 0.50 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1386612 | 0.88 | GRM4 (0.59) | GRM4HDAC6NPC1RAB9AKDR | |
| SCHEMBL28501806 | 0.82 | GRM4 (0.68) | GRM4HDAC6NPC1RAB9AKDR | |
| SCHEMBL29516188 | 0.82 | GRM4 (0.68) | GRM4HDAC6NPC1RAB9AKDR | |
| SCHEMBL1383789 | 0.81 | GRM5 (0.51) | RAB9AMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL17685484 | 0.79 | MAPT (0.51) | GRM4HDAC6NPC1RAB9AKDR | |
| SCHEMBL14284353 | 0.77 | GRM4 (0.73) | GRM4HDAC6NPC1RAB9AKDR | |
| SCHEMBL29496401 | 0.76 | GRM4 (1.00) | GRM4HDAC6NPC1RAB9AKDR | |
| SCHEMBL2530324 | 0.76 | GRM4 (1.00) | GRM4HDAC6NPC1RAB9AKDR | |
| SCHEMBL16007573 | 0.76 | KDR (0.70) | GRM4HDAC6RAB9AKDRSMN1; SMN2 | |
| SCHEMBL4134533 | 0.75 | DHODH (0.62) | NPC1RAB9ASMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4774410-B2 | — | — | 2011-09-14 | — | — | JP | claimed |
| US-7947685-B2 | Pyrazine-2-carboxyamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-24 | — | — | US | disclosed |