Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 8/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | PPIA | P62937 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17685492 | 0.89 | MEN1 (0.50) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL17685495 | 0.82 | PORCN (0.49) | MAPTRAB9AMEN1KMT2ALMNA | |
| SCHEMBL2827687 | 0.80 | MEN1 (0.49) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL1385162 | 0.79 | GRM4 (0.61) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL3983149 | 0.76 | KMT2A (0.66) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL30063912 | 0.76 | KMT2A (0.66) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2832150 | 0.74 | KMT2A (0.50) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2830058 | 0.74 | LMNA (0.50) | MAPTNPC1RAB9AMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL17685482 | 0.73 | KMT2A (0.45) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2829161 | 0.71 | HPGD (0.50) | MAPTNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858862-B1 | PYRAZINE -2-CARBOXAMIDE DERIVATIVES AS mGluR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2016-04-20 | — | — | EP | claimed |