Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.51 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.46 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | PRKCI | P41743 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1385162 | 0.81 | GRM4 (0.61) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL17685495 | 0.79 | PORCN (0.49) | GRM5SORT1MEN1KMT2AALDH1A1 | |
| SCHEMBL3989785 | 0.78 | JAK2 (0.60) | SORT1MEN1KMT2AMAPTSMARCA2 | |
| SCHEMBL12595503 | 0.78 | RAB9A (0.60) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL24010657 | 0.77 | BRAF (0.57) | MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL30290919 | 0.77 | BRAF (0.57) | MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL30232524 | 0.77 | KCNK3 (0.55) | MEN1KMT2AJAK2 | |
| SCHEMBL24003834 | 0.77 | KCNK3 (0.55) | MEN1KMT2AJAK2 | |
| SCHEMBL1761110 | 0.77 | SORT1 (0.60) | GRM5SORT1MEN1KMT2AALDH1A1 | |
| SCHEMBL9828922 | 0.76 | SMARCA2 (0.69) | SORT1MEN1KMT2AMAPTSMARCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4774410-B2 | — | — | 2011-09-14 | — | — | JP | claimed |
| US-7947685-B2 | Pyrazine-2-carboxyamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-24 | — | — | US | disclosed |