Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13852918 | 0.78 | KDM4E (0.46) | KDM4EALDH1A1MAPTHPGDMTNR1A | |
| SCHEMBL13852787 | 0.76 | KDM4E (0.56) | KDM4EALDH1A1MAPTHPGDMTNR1A | |
| SCHEMBL13852792 | 0.75 | BAZ2B (0.48) | KDM4EALDH1A1MAPTHPGDMTNR1A | |
| SCHEMBL13852781 | 0.71 | KDM4E (0.53) | KDM4EALDH1A1MAPTHPGDMTNR1A | |
| SCHEMBL8058469 | 0.69 | PARP1 (0.66) | — | |
| SCHEMBL8794276 | 0.69 | KDM4E (0.68) | KDM4EALDH1A1MAPTHPGDMTNR1A | |
| SCHEMBL1987936 | 0.68 | MEN1 (0.50) | KDM4EALDH1A1MAPTHPGDMTNR1A | |
| SCHEMBL6234998 | 0.67 | KDM4E (0.65) | KDM4EALDH1A1MAPTHPGDMTNR1A | |
| SCHEMBL4142893 | 0.67 | KDM4E (0.69) | KDM4EALDH1A1MAPTHPGDMTNR1A | |
| SCHEMBL3033917 | 0.66 | KDM4E (1.00) | KDM4EALDH1A1MAPTHPGDMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131407-A1 | TETRACYCLIC KINASE INHIBITORS | GENENTECH, INC. | 2009-05-21 | — | — | US | disclosed |
| US-20090131407-A1 | TETRACYCLIC KINASE INHIBITORS | GENENTECH, INC. | 2009-05-21 | — | — | US | disclosed |
| WO-2007120333-A2 | TETRACYCLIC KINASE INHIBITORS | GENENTECH, INC. (US) | 2007-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131407-A1 | TETRACYCLIC KINASE INHIBITORS | CNKSR1, MAP3K19, BRAF | KDM4E 1144/4885ALDH1A1 3634/4885MAPT 3831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.