Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | PGR | P06401 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.54 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13629279 | 0.88 | PGR (0.60) | ALDH1A1PGRTP53UCHL1LMNA | |
| SCHEMBL10456537 | 0.82 | PGR (0.65) | ALDH1A1PGRHDAC3HDAC4HDAC1 | |
| SCHEMBL28747153 | 0.82 | ALDH1A1 (0.53) | ALDH1A1PGRTP53LMNAMAPT | |
| SCHEMBL13853039 | 0.82 | SLC22A12 (0.64) | ALDH1A1PGRHDAC3HDAC4HDAC1 | |
| SCHEMBL3769126 | 0.81 | PGR (0.73) | ALDH1A1PGRHDAC3HDAC4HDAC1 | |
| SCHEMBL27761877 | 0.81 | ALDH1A1 (0.63) | ALDH1A1PGRHDAC3HDAC4HDAC1 | |
| SCHEMBL13629320 | 0.80 | SLC22A12 (0.54) | ALDH1A1PGRHDAC3HDAC4HDAC1 | |
| SCHEMBL13852828 | 0.79 | PGR (0.61) | ALDH1A1PGRHDAC3HDAC4HDAC1 | |
| SCHEMBL96292 | 0.79 | PGR (0.65) | ALDH1A1PGRHDAC3HDAC4HDAC1 | |
| SCHEMBL29118833 | 0.79 | PGR (0.65) | ALDH1A1PGRHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118277-A1 | 3 Unsubstituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidines as Kinase Inhibitors | NOVARTIS AG | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118277-A1 | 3 Unsubstituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidines as Kinase Inhibitors | TIE1, TEK, MATK | ALDH1A1 2057/4885PGR 1506/4885HDAC3 2201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.