Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 17/20 | 0.84 |
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | HTT | P42858 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | HRH1 | P35367 | 2/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.75 |
| ▸ | LTA4H | P09960 | 1/20 | 0.68 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.67 |
| ▸ | HRH2 | P25021 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1385705 | 1.00 | HRH3 (0.84) | HRH3MEN1LMNAHTTKMT2A | |
| SCHEMBL7434707 | 0.95 | HRH3 (0.88) | HRH3MEN1LMNAHTTKMT2A | |
| SCHEMBL1385417 | 0.92 | LTA4H (0.79) | HRH3MEN1LMNAHTTKMT2A | |
| SCHEMBL12050645 | 0.92 | HRH3 (1.00) | HRH3HRH1KCNH2HRH4HRH2 | |
| SCHEMBL4094339 | 0.92 | HRH3 (1.00) | HRH3HRH1KCNH2HRH4HRH2 | |
| SCHEMBL12050718 | 0.90 | HRH3 (0.96) | HRH3HRH1KCNH2LTA4HHRH4 | |
| SCHEMBL7403863 | 0.89 | HRH3 (1.00) | HRH3MEN1LMNAHTTKMT2A | |
| Hydrochloric Acid SCHEMBL7397299 | 0.88 | HRH3 (0.97) | HRH3MEN1LMNAHTTKMT2A | |
| SCHEMBL490523 | 0.87 | MEN1 (1.00) | HRH3MEN1LMNAHTTKMT2A | |
| SCHEMBL13698801 | 0.87 | LTA4H (0.87) | HRH3MEN1LMNAHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4806149-B2 | — | — | 2011-11-02 | — | — | JP | claimed |
| EP-1216244-A1 | Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as D4 antagonists | Aventis Pharmaceuticals Inc. (US) | 2002-06-26 | — | — | EP | claimed |
| WO-2001019821-A1 | BENZISOXAZOLYL-, PYRIDOISOXAZOLYL- AND BENZTHIENYL-PHENOXY DERIVATIVES USEFUL AS D4 ANTAGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-03-22 | — | — | WO | claimed |