Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 1.00 |
| ▸ | USP2 | O75604 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 2/20 | 1.00 |
| ▸ | NR4A1 | P22736 | 2/20 | 1.00 |
| ▸ | MCL1 | Q07820 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.74 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.74 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13856593 | 0.87 | MAPT (1.00) | MAPTKMT2AUSP2KDM4EMAPK1 | |
| SCHEMBL12259191 | 0.84 | MAPT (0.72) | MAPTKMT2AUSP2KDM4EMAPK1 | |
| SCHEMBL12259128 | 0.81 | KDM4E (0.68) | MAPTKMT2AUSP2KDM4EMAPK1 | |
| SCHEMBL740618 | 0.79 | HPGD (0.74) | MAPTKMT2AUSP2KDM4EMAPK1 | |
| SCHEMBL7825762 | 0.79 | KMT2A (0.81) | MAPTKMT2AUSP2KDM4EMAPK1 | |
| SCHEMBL13856477 | 0.78 | MAPT (1.00) | MAPTKMT2AUSP2KDM4EMAPK1 | |
| SCHEMBL24355430 | 0.77 | MAPT (1.00) | MAPTKMT2AUSP2KDM4EMAPK1 | |
| SCHEMBL6265254 | 0.74 | POLB (0.78) | MAPTKMT2AUSP2KDM4EMAPK1 | |
| SCHEMBL30555325 | 0.73 | HTT (0.97) | MAPTKMT2AUSP2KDM4EMAPK1 | |
| SCHEMBL14119591 | 0.72 | ALDH1A1 (1.00) | MAPTKMT2AUSP2KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | BCL2, BAX, BAD | MAPT 3866/4885KMT2A 4047/4885USP2 816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.