Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1386356 | 0.97 | LMNA (0.46) | LMNASMN1; SMN2MEN1HPGDKMT2A | |
| SCHEMBL1417234 | 0.90 | MAPK14 (0.46) | LMNASMN1; SMN2MAPK14L3MBTL1ROCK2 | |
| SCHEMBL2218015 | 0.87 | LMNA (0.45) | LMNASMN1; SMN2MAPK14L3MBTL1ROCK2 | |
| SCHEMBL1382659 | 0.82 | MAPK14 (0.50) | HPGDMAPK14 | |
| SCHEMBL1416943 | 0.81 | MAPK14 (0.47) | LMNAMAPK14 | |
| SCHEMBL1386596 | 0.78 | LMNA (0.55) | LMNAMAPK14 | |
| SCHEMBL11982571 | 0.76 | MAPK14 (0.48) | HPGDMAPK14 | |
| SCHEMBL1385239 | 0.74 | MAPK14 (0.49) | SMN1; SMN2HPGDMAPK14 | |
| SCHEMBL1383938 | 0.74 | MAPK14 (0.58) | LMNASMN1; SMN2MAPK14ROCK2ROCK1 | |
| SCHEMBL2217376 | 0.73 | MAPK14 (0.45) | LMNASMN1; SMN2MAPK14ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4838121-B2 | — | — | 2011-12-14 | — | — | JP | claimed |
| JP-2007521278-A | — | — | 2007-08-02 | — | — | JP | claimed |
| EP-1641764-A1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | Novartis AG (CH) | 2006-04-05 | — | — | EP | claimed |
| WO-2005009973-A1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | NOVARTIS AG (CH) | 2005-02-03 | — | — | WO | claimed |