Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1386356 | 0.90 | LMNA (0.46) | LMNASMN1; SMN2MAPK14ROCK2ROCK1 | |
| SCHEMBL1417234 | 0.87 | MAPK14 (0.46) | LMNASMN1; SMN2MAPK14ROCK2ROCK1 | |
| SCHEMBL1385656 | 0.87 | LMNA (0.45) | LMNASMN1; SMN2MAPK14ROCK2ROCK1 | |
| SCHEMBL2215104 | 0.82 | MAPK14 (0.46) | LMNAMAPK14 | |
| SCHEMBL2216787 | 0.79 | MAPK14 (0.48) | MAPK14 | |
| SCHEMBL2217376 | 0.76 | MAPK14 (0.45) | LMNASMN1; SMN2MAPK14ROCK2ROCK1 | |
| SCHEMBL2214450 | 0.76 | MAPK14 (0.46) | MAPK14L3MBTL1 | |
| SCHEMBL1383938 | 0.76 | MAPK14 (0.58) | LMNASMN1; SMN2MAPK14ROCK2ROCK1 | |
| SCHEMBL11982588 | 0.74 | MAPK14 (0.52) | LMNASMN1; SMN2MAPK14ROCK2ROCK1 | |
| SCHEMBL1416943 | 0.72 | MAPK14 (0.47) | LMNAMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641764-B1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-07-27 | — | — | EP | claimed |