Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | THRB | P10828 | 3/20 | 1.00 |
| ▸ | RECQL | P46063 | 3/20 | 1.00 |
| ▸ | P2RX7 | Q99572 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 1.00 |
| ▸ | BRCA1 | P38398 | 1/20 | 1.00 |
| ▸ | CDK2 | P24941 | 1/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.77 |
| ▸ | THPO | P40225 | 2/20 | 0.77 |
| ▸ | POLB | P06746 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30533406 | 1.00 | MAPT (1.00) | MAPTTDP1KDM4EMEN1KMT2A | |
| SCHEMBL14506114 | 1.00 | MAPT (1.00) | MAPTTDP1KDM4EMEN1KMT2A | |
| SCHEMBL16450977 | 0.93 | MAPT (0.87) | MAPTTDP1KDM4EMEN1KMT2A | |
| SCHEMBL16325955 | 0.88 | MAPT (0.79) | MAPTTDP1KDM4EMEN1KMT2A | |
| SCHEMBL29381820 | 0.87 | MAPT (1.00) | MAPTTDP1KDM4EMEN1KMT2A | |
| SCHEMBL13961828 | 0.82 | P2RY1 (0.74) | MAPTTDP1KDM4EMEN1KMT2A | |
| SCHEMBL13962116 | 0.78 | P2RY1 (1.00) | MAPTTDP1KDM4EMEN1KMT2A | |
| Isoppads SCHEMBL14702227 | 0.78 | MAPT (1.00) | MAPTTDP1KDM4EMEN1KMT2A | |
| SCHEMBL13624677 | 0.78 | MAPT (1.00) | MAPTTDP1KDM4EMEN1KMT2A | |
| SCHEMBL31236767 | 0.78 | MAPT (1.00) | MAPTTDP1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | BCL2, BAX, BAD | MAPT 3866/4885TDP1 2043/4885KDM4E 3373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.