Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 1.00 |
| ▸ | P2RX3 | P56373 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.86 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.86 |
| ▸ | P2RX5 | Q93086 | 2/20 | 0.86 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.86 |
| ▸ | CASP1 | P29466 | 1/20 | 0.86 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.86 |
| ▸ | RAB9A | P51151 | 1/20 | 0.86 |
| ▸ | CASP7 | P55210 | 1/20 | 0.86 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.74 |
| ▸ | THRB | P10828 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isoppads SCHEMBL29494952 | 1.00 | MAPT (1.00) | MAPTTDP1P2RX3KDM4EP2RX2 | |
| SCHEMBL7196930 | 0.93 | MAPT (1.00) | MAPTTDP1P2RX3KDM4EP2RX2 | |
| SCHEMBL5287746 | 0.93 | MAPT (1.00) | MAPTTDP1P2RX3KDM4EP2RX2 | |
| SCHEMBL31236767 | 0.93 | MAPT (1.00) | MAPTTDP1P2RX3KDM4EP2RX2 | |
| SCHEMBL13624677 | 0.93 | MAPT (1.00) | MAPTTDP1P2RX3KDM4EP2RX2 | |
| SCHEMBL7196945 | 0.93 | MAPT (1.00) | MAPTTDP1P2RX3KDM4EP2RX2 | |
| SCHEMBL29357199 | 0.93 | MAPT (1.00) | MAPTTDP1P2RX3KDM4EP2RX2 | |
| SCHEMBL29374112 | 0.88 | MAPT (0.78) | MAPTTDP1P2RX3KDM4EP2RX2 | |
| SCHEMBL16450980 | 0.87 | MAPT (0.79) | MAPTTDP1P2RX3KDM4EP2RX2 | |
| SCHEMBL14506104 | 0.86 | MAPT (0.75) | MAPTTDP1P2RX3KDM4EP2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9546139-B2 | Pyridine carboxylic acid based compound used as a P2X1 and P2X3 receptor antagonist, a production method for the same and a composition comprising the same | GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2017-01-17 | — | — | US | disclosed |
| US-9546139-B2 | Pyridine carboxylic acid based compound used as a P2X1 and P2X3 receptor antagonist, a production method for the same and a composition comprising the same | GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2017-01-17 | — | — | US | disclosed |
| US-9034798-B2 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | CAPROTEC BIOANALYTICS GMBH (DE) | 2015-05-19 | — | — | US | disclosed |
| US-8569481-B2 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | PHARMACEUTICALS, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-20130040997-A1 | NOVEL PYRIDINE CARBOXYLIC ACID BASED COMPOUND USED AS A P2X1 AND P2X3 RECEPTOR ANTAGONIST, A PRODUCTION METHOD FOR THE SAME AND A COMPOSITION COMPRISING THE SAME | GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2013-02-14 | — | — | US | disclosed |
| US-20130040997-A1 | NOVEL PYRIDINE CARBOXYLIC ACID BASED COMPOUND USED AS A P2X1 AND P2X3 RECEPTOR ANTAGONIST, A PRODUCTION METHOD FOR THE SAME AND A COMPOSITION COMPRISING THE SAME | GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2013-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040997-A1 | NOVEL PYRIDINE CARBOXYLIC ACID BASED COMPOUND USED AS A P2X1 AND P2X3 RECEPTOR ANTAGONIST, A PRODUCTION METHOD FOR THE SAME AND A COMPOSITION COMPRISING THE SAME | P2RX3, P2RX1, P2RX2 | MAPT 2226/4885TDP1 3900/4885P2RX3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.