Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 9/20 | 0.55 |
| ▸ | NOS3 | P29474 | 3/20 | 0.37 |
| ▸ | NOS1 | P29475 | 3/20 | 0.37 |
| ▸ | NOS2 | P35228 | 3/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5773953 | 0.89 | SLC2A1 (0.53) | SLC2A1NOS3NOS1NOS2KCNH2 | |
| SCHEMBL13857009 | 0.83 | SLC2A1 (0.65) | SLC2A1KCNH2 | |
| SCHEMBL4270077 | 0.77 | NTRK1 (0.44) | NOS3NOS1NOS2 | |
| SCHEMBL13857012 | 0.73 | SLC2A1 (0.55) | SLC2A1KCNH2 | |
| SCHEMBL4270492 | 0.73 | SLC2A1 (0.50) | SLC2A1 | |
| SCHEMBL5797424 | 0.73 | SLC2A1 (0.64) | SLC2A1KCNH2 | |
| SCHEMBL14498889 | 0.68 | KCNH2 (0.49) | KCNH2 | |
| SCHEMBL4277304 | 0.68 | GSK3A (0.42) | — | |
| SCHEMBL14341258 | 0.67 | KCNH2 (0.48) | KCNH2 | |
| SCHEMBL14523985 | 0.67 | KCNH2 (0.48) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534793-B2 | Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity | SMITHKLINE BEECHAM P.L.C. (GB) | 2009-05-19 | — | — | US | disclosed |
| US-7534793-B2 | Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity | SMITHKLINE BEECHAM P.L.C. (GB) | 2009-05-19 | — | — | US | disclosed |