Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 10/20 | 0.45 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 4/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16236759 | 0.85 | ADK (0.47) | ADKSLC29A1ABL1DAPK3MAP4K4 | |
| SCHEMBL1939761 | 0.81 | ADK (0.52) | ADKSLC29A1ABL1DAPK3MAP4K4 | |
| SCHEMBL401328 | 0.81 | ADK (0.52) | ADKSLC29A1ABL1DAPK3MAP4K4 | |
| SCHEMBL30373169 | 0.80 | ADK (0.51) | ADKSLC29A1ABL1DAPK3MAP4K4 | |
| SCHEMBL22086530 | 0.80 | ADK (0.51) | ADKSLC29A1ABL1DAPK3MAP4K4 | |
| SCHEMBL16236685 | 0.80 | ADK (0.51) | ADKSLC29A1ABL1DAPK3MAP4K4 | |
| SCHEMBL20351805 | 0.80 | ADK (0.47) | ADKSLC29A1ABL1DAPK3MAP4K4 | |
| SCHEMBL16236581 | 0.80 | ADK (0.49) | ADKSLC29A1HTR6MTORRAB9A | |
| SCHEMBL13858155 | 0.79 | SRC (0.53) | ADKSLC29A1ABL1SRCEGFR | |
| SCHEMBL15516700 | 0.79 | SRC (0.53) | ADKSLC29A1ABL1SRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2710005-A1 | TYROSINE KINASE INHIBITORS | Principia Biopharma Inc. (US) | 2014-03-26 | — | — | EP | disclosed |
| WO-2012158764-A1 | TYROSINE KINASE INHIBITORS | PRINCIPIA BIOPHARMA INC. (US) | 2012-11-22 | — | — | WO | disclosed |