Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 11/20 | 0.46 |
| ▸ | JAK1 | P23458 | 11/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.43 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13858221 | 0.87 | POLB (0.47) | POLBMEN1KMT2AJAK2JAK1 | |
| SCHEMBL2224318 | 0.82 | GPR119 (0.53) | POLBJAK2JAK1OPRD1OPRK1 | |
| SCHEMBL20744340 | 0.81 | JAK2 (0.48) | POLBMEN1KMT2AJAK2JAK1 | |
| SCHEMBL11963131 | 0.79 | STS (0.49) | POLBMEN1KMT2AJAK2JAK1 | |
| SCHEMBL2588263 | 0.78 | MEN1 (0.55) | POLBMEN1KMT2AOPRD1OPRK1 | |
| SCHEMBL12175568 | 0.78 | POLB (0.41) | POLBMEN1KMT2AJAK2JAK1 | |
| SCHEMBL28405975 | 0.77 | RORC (0.42) | POLBJAK2JAK1 | |
| SCHEMBL12178960 | 0.77 | TRPV1 (0.57) | POLBMEN1KMT2AOPRD1OPRK1 | |
| SCHEMBL4294944 | 0.77 | TRPV1 (0.42) | POLBMEN1KMT2AJAK2JAK1 | |
| SCHEMBL5473436 | 0.76 | GPR119 (0.52) | POLBJAK2JAK1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2709621-B1 | N-LINKED QUINOLINEAMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2016-11-02 | — | — | EP | disclosed |
| EP-2709621-B1 | N-LINKED QUINOLINEAMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2016-11-02 | — | — | EP | disclosed |
| US-8940765-B2 | N-linked quinolineamide M1 receptor positive allosteric modulators | MERCK SHARP & DOHME CORP. (US) | 2015-01-27 | — | — | US | disclosed |
| US-8940765-B2 | N-linked quinolineamide M1 receptor positive allosteric modulators | MERCK SHARP & DOHME CORP. (US) | 2015-01-27 | — | — | US | disclosed |
| US-8940765-B2 | N-linked quinolineamide M1 receptor positive allosteric modulators | MERCK SHARP & DOHME CORP. (US) | 2015-01-27 | — | — | US | disclosed |
| US-20140200222-A1 | N-LINKED QUINOLINEAMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME LLC | 2014-07-17 | — | — | US | disclosed |
| US-20140200222-A1 | N-LINKED QUINOLINEAMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME LLC | 2014-07-17 | — | — | US | disclosed |
| EP-2709621-A1 | N-LINKED QUINOLINEAMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck Sharp & Dohme Corp. (US) | 2014-03-26 | — | — | EP | disclosed |
| WO-2012158474-A1 | N-LINKED QUINOLINEAMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2012-11-22 | — | — | WO | disclosed |
| WO-2012158474-A1 | N-LINKED QUINOLINEAMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2012-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140200222-A1 | N-LINKED QUINOLINEAMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | CHRM1, OPRL1, CHRM2 | POLB 3163/4885MEN1 3053/4885KMT2A 779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.