Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13721165 | 0.92 | KMT2A (0.48) | KDM4EHPGDKMT2AMEN1ALDH1A1 | |
| SCHEMBL13720819 | 0.89 | KDM4E (0.45) | KDM4EHPGDKMT2AMEN1ALDH1A1 | |
| SCHEMBL13721379 | 0.88 | MEN1 (0.46) | KDM4EHPGDKMT2AMEN1ALDH1A1 | |
| SCHEMBL13721316 | 0.88 | KDM4E (0.45) | KDM4EHPGDKMT2AMEN1ALDH1A1 | |
| SCHEMBL16155964 | 0.85 | AKR1B1 (0.45) | KDM4EHPGDKMT2AMEN1ALDH1A1 | |
| SCHEMBL13720757 | 0.81 | KDM4E (0.41) | KDM4EHPGDKMT2AMEN1ALDH1A1 | |
| SCHEMBL13721378 | 0.81 | HPGD (0.47) | KDM4EHPGDKMT2AMEN1ALDH1A1 | |
| SCHEMBL13721003 | 0.81 | KDM4E (0.49) | KDM4EHPGDKMT2AMEN1ALDH1A1 | |
| SCHEMBL13858680 | 0.80 | KDM4E (0.45) | KDM4EHPGDKMT2AMEN1ALDH1A1 | |
| SCHEMBL30824700 | 0.79 | KDM4E (0.54) | KDM4EHPGDKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012158399-A1 | CONDENSED 2 - CARBAMOYLPYRIDAZINONES AS POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-11-22 | — | — | WO | claimed |
| WO-2012158399-A1 | CONDENSED 2 - CARBAMOYLPYRIDAZINONES AS POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-11-22 | — | — | WO | disclosed |