Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | BRD4 | O60885 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | AR | P10275 | 3/20 | 0.58 |
| ▸ | PARP1 | P09874 | 1/20 | 0.58 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6340069 | 0.87 | BRD4 (0.75) | KDM4EPOLBLMNABRD4TDP1 | |
| SCHEMBL17444767 | 0.87 | KDM4E (0.73) | KDM4EPOLBLMNABRD4TDP1 | |
| SCHEMBL4713932 | 0.86 | SMN1; SMN2 (0.61) | KDM4EPOLBLMNABRD4TDP1 | |
| SCHEMBL25231678 | 0.83 | KDM4E (0.49) | KDM4EPOLBALDH1A1GAASMN1; SMN2 | |
| SCHEMBL27002224 | 0.80 | BRD4 (0.51) | KDM4EPOLBLMNABRD4TDP1 | |
| SCHEMBL2610104 | 0.80 | KDM4E (1.00) | KDM4EPOLBLMNATDP1KMT2A | |
| SCHEMBL25215003 | 0.80 | ROCK2 (0.77) | KDM4EPOLB | |
| SCHEMBL5165966 | 0.79 | MAPT (0.78) | KDM4EPOLBLMNAKMT2AMAPT | |
| SCHEMBL17444764 | 0.79 | TDP1 (0.57) | KDM4EPOLBLMNABRD4TDP1 | |
| SCHEMBL17444766 | 0.79 | KDM4E (0.60) | KDM4EPOLBLMNABRD4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012158399-A1 | CONDENSED 2 - CARBAMOYLPYRIDAZINONES AS POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-11-22 | — | — | WO | disclosed |