Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | PARP1 | P09874 | 4/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 3/20 | 0.49 |
| ▸ | GABRP | O00591 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17444767 | 0.89 | KDM4E (0.73) | KDM4EPOLBPARP1BRD4TDP1 | |
| SCHEMBL17444769 | 0.80 | KDM4E (0.57) | KDM4EPOLBPARP1BRD4TDP1 | |
| SCHEMBL17444764 | 0.80 | TDP1 (0.57) | KDM4EPOLBPARP1BRD4TDP1 | |
| SCHEMBL13858810 | 0.79 | KDM4E (0.66) | KDM4EPOLBPARP1BRD4TDP1 | |
| SCHEMBL7122967 | 0.79 | AR (0.77) | PARP1LMNAAR | |
| SCHEMBL17444768 | 0.79 | AR (0.64) | KDM4EPOLBPARP1BRD4TDP1 | |
| SCHEMBL4713932 | 0.78 | SMN1; SMN2 (0.61) | KDM4EPOLBPARP1BRD4TDP1 | |
| SCHEMBL6783793 | 0.76 | BRD4 (0.53) | KDM4EPARP1BRD4TDP1LMNA | |
| SCHEMBL6340069 | 0.76 | BRD4 (0.75) | KDM4EPOLBPARP1BRD4TDP1 | |
| SCHEMBL18415459 | 0.75 | LMNA (0.66) | POLBLMNAALDH1A1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9797882-B2 | Method of screening for a compound for inhibitory activity of FN14-tweak interaction | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2017-10-24 | — | — | US | disclosed |
| US-9797882-B2 | Method of screening for a compound for inhibitory activity of FN14-tweak interaction | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2017-10-24 | — | — | US | disclosed |
| US-20160146784-A1 | COMPOSITIONS AND METHODS OF SCREENING FOR COMPOUNDS THAT MODULATE ACTIVITY AT A TWEAK BINDING SITE ON A CRD OF FN14 | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE | 2016-05-26 | — | — | US | disclosed |
| US-20160146784-A1 | COMPOSITIONS AND METHODS OF SCREENING FOR COMPOUNDS THAT MODULATE ACTIVITY AT A TWEAK BINDING SITE ON A CRD OF FN14 | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE | 2016-05-26 | — | — | US | disclosed |
| US-9238034-B2 | FN14 antagonists and therapeutic uses thereof | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2016-01-19 | — | — | US | disclosed |
| US-9238034-B2 | FN14 antagonists and therapeutic uses thereof | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2016-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160146784-A1 | COMPOSITIONS AND METHODS OF SCREENING FOR COMPOUNDS THAT MODULATE ACTIVITY AT A TWEAK BINDING SITE ON A CRD OF FN14 | FN1, ST14, TNFRSF1A | KDM4E 4405/4885POLB 4820/4885PARP1 4176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.