Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18894093 | 0.82 | ALDH1A1 (0.33) | TDP1POLBALDH1A1MAPTALOX15 | |
| SCHEMBL587048 | 0.79 | ALDH1A1 (0.46) | TDP1KDM4EPOLBCTDSP1L3MBTL1 | |
| SCHEMBL5495434 | 0.79 | ALDH1A1 (0.38) | KDM4EPOLBL3MBTL1MEN1KMT2A | |
| SCHEMBL5165930 | 0.79 | ALDH1A1 (0.40) | KDM4EPOLBCTDSP1MEN1KMT2A | |
| SCHEMBL577619 | 0.78 | ALDH1A1 (0.37) | KDM4EPOLBL3MBTL1MEN1KMT2A | |
| SCHEMBL25388605 | 0.75 | ALDH1A1 (0.38) | POLBMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL4617532 | 0.75 | TDP1 (0.55) | TDP1POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL1531294 | 0.75 | HTT (0.57) | TDP1MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL16794991 | 0.73 | HTR2A (0.45) | L3MBTL1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1179747 | 0.73 | TDP1 (0.62) | TDP1KDM4EPOLBCTDSP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2709992-A1 | 1,3-OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2014-03-26 | — | — | EP | disclosed |
| WO-2012156284-A1 | 1,3-OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-22 | — | — | WO | disclosed |