Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 13/20 | 0.35 |
| ▸ | EGFR | P00533 | 5/20 | 0.33 |
| ▸ | LCK | P06239 | 5/20 | 0.33 |
| ▸ | ITK | Q08881 | 4/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15516633 | 0.86 | PDE8B (0.40) | JAK3 | |
| SCHEMBL15516634 | 0.86 | PDE8B (0.40) | JAK3 | |
| SCHEMBL28097469 | 0.80 | BTK (0.39) | HRH3BTKEGFRLCKITK | |
| SCHEMBL17312246 | 0.78 | ACACB (0.34) | ACACB | |
| SCHEMBL16492427 | 0.74 | PDE8B (0.39) | JAK3 | |
| SCHEMBL16492428 | 0.74 | PDE8B (0.39) | JAK3 | |
| SCHEMBL29064221 | 0.74 | BTK (0.34) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL29064219 | 0.74 | BTK (0.34) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL28928067 | 0.73 | LMNA (0.37) | — | |
| SCHEMBL29064397 | 0.72 | BTK (0.39) | ACACBBTKEGFRLCKITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103534258-B | Tyrosine kinase inhibitor | 普林斯匹亚生物制药公司 | 2016-09-14 | — | — | CN | disclosed |
| EP-2710005-A1 | TYROSINE KINASE INHIBITORS | Principia Biopharma Inc. (US) | 2014-03-26 | — | — | EP | disclosed |
| WO-2012158764-A1 | TYROSINE KINASE INHIBITORS | PRINCIPIA BIOPHARMA INC. (US) | 2012-11-22 | — | — | WO | disclosed |