Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIB | P23284 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25223531 | 1.00 | PPIB (0.58) | PPIBCYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL25274049 | 0.88 | PPIB (0.57) | PPIBCYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL29396441 | 0.88 | PPIB (0.57) | PPIBCYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL25274050 | 0.88 | PPIB (0.57) | PPIBCYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL25927732 | 0.85 | PPIB (0.56) | PPIBCYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL7370305 | 0.84 | PPIB (0.53) | PPIBCYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL21996709 | 0.83 | LMNA (0.52) | SMN1; SMN2ALDH1A1KDM4ELMNAMAPK1 | |
| SCHEMBL1820365 | 0.82 | PPIB (0.52) | PPIBCYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL15338789 | 0.82 | PPIB (0.52) | PPIBCYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL1502008 | 0.82 | PPIB (0.52) | PPIBCYP1A2CYP2C9CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012158117-A1 | COMBINATION THERAPIES FOR TREATING PAIN | ASTRAZENECA AB (SE) | 2012-11-22 | — | — | WO | disclosed |