Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | SCN1A | P35498 | 4/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13861969 | 0.92 | MEN1 (0.50) | MEN1POLBKMT2AOPRM1CACNA1F | |
| SCHEMBL4371470 | 0.85 | LTA4H (0.41) | KDM1ASCN1ASCN8ALTA4HDDR1 | |
| SCHEMBL14924484 | 0.81 | SCN1A (0.49) | MEN1POLBKMT2AKDM1ASCN1A | |
| SCHEMBL4369274 | 0.80 | ALDH1A1 (0.65) | MEN1KMT2ASCN1ASCN8ADDR1 | |
| SCHEMBL14924455 | 0.80 | LTA4H (0.55) | MEN1POLBKMT2ALTA4HALDH1A1 | |
| SCHEMBL18516568 | 0.80 | LTA4H (0.55) | MEN1POLBKMT2ALTA4HALDH1A1 | |
| SCHEMBL4369101 | 0.79 | KDM4E (0.37) | MEN1KMT2AKDM1ASCN1ASCN8A | |
| SCHEMBL15381987 | 0.79 | DDR1 (0.49) | KDM1ADDR1 | |
| SCHEMBL13861970 | 0.77 | MEN1 (0.52) | MEN1POLBKMT2AKDM1AOPRM1 | |
| SCHEMBL13861967 | 0.76 | KDM4E (0.60) | MEN1POLBKMT2AOPRM1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531553-B2 | Heterocyclic compounds and methods of use | AMGEN INC. (US) | 2009-05-12 | — | — | US | disclosed |
| US-7531553-B2 | Heterocyclic compounds and methods of use | AMGEN INC. (US) | 2009-05-12 | — | — | US | disclosed |
| EP-1664023-B1 | SUSTITUTED ISOQUINOLINE DERIVATIVES AND METHODS OF USE | AMGEN INC (US) | 2008-08-13 | — | — | EP | disclosed |
| US-7390820-B2 | Substituted quinolinone derivatives and methods of use | AMGEN INC. (US) | 2008-06-24 | — | — | US | disclosed |
| US-7390820-B2 | Substituted quinolinone derivatives and methods of use | AMGEN INC. (US) | 2008-06-24 | — | — | US | disclosed |