Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 11/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | LDHB | P07195 | 3/20 | 0.35 |
| ▸ | LDHA | P00338 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL488293 | 0.86 | ATR (0.48) | ATRCSF1R | |
| SCHEMBL30454557 | 0.81 | ATR (0.51) | ATRPIK3CAPIK3CDPIK3CGCSF1R | |
| SCHEMBL488175 | 0.81 | ATR (0.51) | ATRPIK3CAPIK3CDPIK3CGCSF1R | |
| SCHEMBL488637 | 0.79 | LDHA (0.46) | ATRPIK3CAPIK3CDPIK3CGLDHB | |
| SCHEMBL30453342 | 0.79 | LDHA (0.46) | ATRPIK3CAPIK3CDPIK3CGLDHB | |
| SCHEMBL488441 | 0.78 | ATR (0.51) | ATR | |
| SCHEMBL30454216 | 0.78 | ATR (0.51) | ATR | |
| SCHEMBL10216349 | 0.77 | MAP4K4 (0.52) | ATRPIK3CDPIK3CG | |
| SCHEMBL488626 | 0.76 | KCNH2 (0.56) | ATR | |
| SCHEMBL30454874 | 0.76 | KCNH2 (0.56) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4695588-B2 | — | — | 2011-06-08 | — | — | JP | claimed |
| JP-2006519232-A | — | — | 2006-08-24 | — | — | JP | claimed |
| EP-1603570-A2 | AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2005-12-14 | — | — | EP | claimed |
| WO-2004076412-A2 | AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | SUGEN, INC. (US) | 2004-09-10 | — | — | WO | claimed |