Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.58 |
| ▸ | PLAU | P00749 | 3/20 | 0.54 |
| ▸ | HPN | P05981 | 3/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27681821 | 0.93 | ALDH1A1 (0.63) | ALDH1A1LMNAHDAC2PLAUHPN | |
| SCHEMBL13864693 | 0.92 | HDAC2 (0.64) | HDAC2HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL13864784 | 0.91 | MMP9 (0.61) | HDAC2HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL13864752 | 0.90 | HDAC2 (0.59) | HDAC2HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL13864811 | 0.89 | HDAC2 (0.58) | HDAC2HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL13864744 | 0.89 | HDAC2 (0.58) | HDAC2HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL13864751 | 0.89 | HDAC2 (0.62) | HDAC2HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL13864720 | 0.89 | HDAC2 (0.55) | ALDH1A1HDAC2HDAC1HDAC11HDAC8 | |
| SCHEMBL13867750 | 0.88 | HDAC2 (0.56) | HDAC2HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL13864730 | 0.87 | HDAC2 (0.55) | HDAC2HDAC1HDAC11HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534918-B2 | Histone deacetylase inhibitors | MERCK & CO., INC. (US) | 2009-05-19 | — | — | US | disclosed |
| US-7534918-B2 | Histone deacetylase inhibitors | MERCK & CO., INC. (US) | 2009-05-19 | — | — | US | disclosed |
| US-20080015216-A1 | Histone Deacetylase Inhibitors | MERCK SHARP & DOHME LLC | 2008-01-17 | — | — | US | disclosed |
| US-20080015216-A1 | Histone Deacetylase Inhibitors | MERCK SHARP & DOHME LLC | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015216-A1 | Histone Deacetylase Inhibitors | HDAC1, HDAC5, HDAC9 | ALDH1A1 1195/4885LMNA 3114/4885HDAC2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.