Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.56 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.54 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | EP300 | Q09472 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13865067 | 0.85 | HCRTR1 (0.62) | ALDH1A1CYP2C9CYP2C19PABPC1HCRTR1 | |
| SCHEMBL13865069 | 0.83 | HCRTR1 (0.66) | ALDH1A1HCRTR1HCRTR2HTTKDM4E | |
| SCHEMBL17536099 | 0.83 | ALDH1A1 (0.55) | ALDH1A1CYP2C9CYP2C19PABPC1HCRTR1 | |
| SCHEMBL17536047 | 0.83 | ALDH1A1 (0.55) | ALDH1A1CYP2C9CYP2C19PABPC1HCRTR1 | |
| SCHEMBL4799610 | 0.82 | ALDH1A1 (0.64) | ALDH1A1CYP2C9CYP2C19PABPC1MAPK1 | |
| SCHEMBL4799596 | 0.82 | ALDH1A1 (0.64) | ALDH1A1CYP2C9CYP2C19PABPC1MAPK1 | |
| SCHEMBL16602533 | 0.82 | ALDH1A1 (0.59) | ALDH1A1CYP2C9CYP2C19PABPC1HCRTR1 | |
| SCHEMBL27627515 | 0.81 | ALDH1A1 (0.79) | ALDH1A1CYP2C9CYP2C19MAPK1HTT | |
| SCHEMBL15196649 | 0.81 | CYP2C9 (0.60) | ALDH1A1CYP2C9CYP2C19PABPC1HCRTR1 | |
| SCHEMBL16602515 | 0.81 | CYP2C9 (0.60) | ALDH1A1CYP2C9CYP2C19PABPC1HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2628481-B1 | Trisubstituted heterocycles as replication inhibitors of hepatitis C virus HCV | ABBVIE BAHAMAS LTD (BS) | 2016-02-24 | — | — | EP | disclosed |
| US-20090118200-A1 | Proline bis-amide orexin receptor antagonists | MERCK SHARP & DOHME CORP. | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118200-A1 | Proline bis-amide orexin receptor antagonists | HCRTR1, HCRTR2, NPSR1 | ALDH1A1 3973/4885CYP2C9 3987/4885CYP2C19 3031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.