Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | EP300 | Q09472 | 1/20 | 0.54 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4799610 | 1.00 | ALDH1A1 (0.64) | ALDH1A1CYP2C9CYP2C19HTTMAPK1 | |
| SCHEMBL4742813 | 0.95 | ALDH1A1 (0.60) | ALDH1A1CYP2C9CYP2C19HTTMAPK1 | |
| SCHEMBL27627515 | 0.89 | ALDH1A1 (0.79) | ALDH1A1CYP2C9CYP2C19HTTMAPK1 | |
| SCHEMBL4978089 | 0.89 | ALDH1A1 (0.67) | ALDH1A1CYP2C9CYP2C19HTTMAPK1 | |
| SCHEMBL2442864 | 0.87 | HTT (0.54) | ALDH1A1CYP2C9CYP2C19HTTMAPK1 | |
| SCHEMBL31722815 | 0.87 | ALDH1A1 (0.60) | ALDH1A1CYP2C9CYP2C19HTTMAPK1 | |
| SCHEMBL3106245 | 0.87 | RHOC (0.62) | ALDH1A1CYP2C9CYP2C19HTTMAPK1 | |
| SCHEMBL3106237 | 0.87 | RHOC (0.62) | ALDH1A1CYP2C9CYP2C19HTTMAPK1 | |
| SCHEMBL9282043 | 0.87 | KCNH2 (0.56) | ALDH1A1CYP2C9CYP2C19HTTMAPK1 | |
| SCHEMBL9282048 | 0.87 | KCNH2 (0.56) | ALDH1A1CYP2C9CYP2C19HTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378521-B2 | Preparation of 2-(2-arylmorpholin-2-yl) ethanol derivatives and intermediates | SANOFI-AVENTIS (FR) | 2008-05-27 | — | — | US | disclosed |
| US-20070167623-A1 | PREPARATION OF 2-(2-ARYLMORPHOLIN-2-YL) ETHANOL DERIVATIVES AND INTERMEDIATES | SANOFI-AVENTIS (FR) | 2007-07-19 | — | — | US | disclosed |
| US-7223860-B2 | Preparation of 2-(2-arylmorpholin-2-yl) ethanol derivatives and intermediates | SANOFI-AVENTIS (FR) | 2007-05-29 | — | — | US | disclosed |
| US-20060149058-A1 | Preparation of 2-(2-arylmorpholin-2-yl) ethanol derivatives and intermediates | SANOFI-AVENTIS (FR) | 2006-07-06 | — | — | US | disclosed |
| US-7038044-B1 | Method for preparing 2-(2-arylmorpholin-2-yl)ethanol derivatives and intermediates | SANOFI-AVENTIS (FR) | 2006-05-02 | — | — | US | disclosed |
| EP-1200417-B1 | METHOD FOR PREPARING 2-(2-ARYLMORPHOLIN-2-YL)ETHANOL DERIVATIVES AND INTERMEDIATES | SANOFI SYNTHELABO (FR) | 2003-10-22 | — | — | EP | disclosed |
| EP-1200417-A1 | METHOD FOR PREPARING 2-(2-ARYLMORPHOLIN-2-YL)ETHANOL DERIVATIVES AND INTERMEDIATES | SANOFI-SYNTHELABO (FR) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001004105-A1 | METHOD FOR PREPARING 2-(2-ARYLMORPHOLIN-2-YL)ETHANOL DERIVATIVES AND INTERMEDIATES | SANOFI-SYNTHELABO (FR) | 2001-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167623-A1 | PREPARATION OF 2-(2-ARYLMORPHOLIN-2-YL) ETHANOL DERIVATIVES AND INTERMEDIATES | ADH1C, ADH1A, ADH5 | ALDH1A1 108/4885CYP2C9 528/4885CYP2C19 651/4885 |
| US-20060149058-A1 | Preparation of 2-(2-arylmorpholin-2-yl) ethanol derivatives and intermediates | ADH1C, ADH1A, ADH5 | ALDH1A1 108/4885CYP2C9 528/4885CYP2C19 651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.