Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 19/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 11/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | SRSF6 | Q13247 | 1/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18218109 | 0.90 | ADRB2 (0.68) | ADRB2ADRB1SLC6A2ADRA1DHTR2A | |
| SCHEMBL21204863 | 0.86 | ADRB2 (0.66) | ADRB2ADRB1SLC6A2ADRA1DHTR2A | |
| SCHEMBL13868999 | 0.84 | ADRB2 (0.49) | ADRB2ADRB1SLC6A2ADRA1DHTR2A | |
| SCHEMBL16067282 | 0.84 | ADRB2 (0.49) | ADRB2ADRB1SLC6A2ADRA1DHTR2A | |
| SCHEMBL13865483 | 0.81 | ADRB2 (0.47) | ADRB2ADRB1SLC6A2ADRA1DHTR2A | |
| SCHEMBL13865479 | 0.81 | ADRB2 (0.81) | ADRB2ADRB1SLC6A2ADRA1DHTR2A | |
| SCHEMBL25993692 | 0.80 | ADRB2 (0.67) | ADRB2ADRB1SLC6A2ADRA1DHTR2A | |
| SCHEMBL865931 | 0.78 | ADRB2 (0.45) | ADRB2ADRB1SLC6A2ADRA1DHTR2A | |
| SCHEMBL13865480 | 0.76 | ADRB2 (0.81) | ADRB2ADRB1SLC6A2ADRA1DHTR2A | |
| SCHEMBL11912040 | 0.72 | ADRB2 (0.46) | ADRB2ADRB1SLC6A2ADRA1DHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534890-B2 | Process for preparing 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1H)-quinolin-2-one salt, useful as an andrenoceptor agonist | NOVARTIS AG (CH) | 2009-05-19 | — | — | US | disclosed |