Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 5/20 | 0.43 |
| ▸ | CDK8 | P49336 | 5/20 | 0.43 |
| ▸ | SMO | Q99835 | 3/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA4 | P22748 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13865716 | 0.87 | PAK1 (0.42) | CCNCCDK8TRPV1CA12CA1 | |
| SCHEMBL13865711 | 0.86 | DRD2 (0.45) | CCNCCDK8TRPV1CA12CA1 | |
| SCHEMBL13865722 | 0.85 | TRPV1 (0.45) | CCNCCDK8TRPV1CA12CA1 | |
| SCHEMBL13865713 | 0.84 | PAK1 (0.41) | CCNCCDK8TRPV1CA12CA1 | |
| SCHEMBL13865714 | 0.83 | TRPV1 (0.43) | TRPV1CA12CA1CA2CA4 | |
| SCHEMBL13865685 | 0.81 | CLK2 (0.43) | CCNCCDK8TRPV1CA12CA1 | |
| SCHEMBL13865712 | 0.81 | PAK1 (0.46) | TRPV1PAK1KDM4ETRPM8SMN1; SMN2 | |
| SCHEMBL13865719 | 0.80 | TRPV1 (0.44) | TRPV1PAK1KDM4ETRPM8 | |
| SCHEMBL13865715 | 0.80 | TRPV1 (0.54) | TRPV1PAK1KDM4ESIGMAR1TDP1 | |
| SCHEMBL13865717 | 0.79 | PAK1 (0.46) | CCNCCDK8TRPV1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528151-B2 | Heterocyclic urea derivatives for the treatment of pain | GLAXO GROUP LIMITED (GB) | 2009-05-05 | — | — | US | disclosed |